Aging-associated mechanisms of atrial fibrillation progression and their therapeutic potential
Atrial fibrillation (AF) is the most common sustained arrhythmia, with a particularly high prevalence in the elderly. As the global aging population rapidly expands, it is increasingly important to examine how alterations to the aging heart contribute to an increased AF susceptibility. This work critically reviews the key molecular mechanisms that may underpin the complex association between aging and AF. Moreover, we identify emerging novel opportunities for therapeutic intervention that may be able to prevent and/or improve the current treatment paradigms for age-related AF. This review contributes to a holistic understanding of the intricate relationship between aging and AF.
Authors
- Xander H.T. Wehrens (ORCID: https://orcid.org/0000-0001-5044-672X)
- Svetlana Reilly (ORCID: https://orcid.org/0000-0003-1231-1239)
- Chi Him Kendrick Yiu (ORCID: https://orcid.org/0000-0001-8070-972X)
- Lucia M. Moreira (ORCID: https://orcid.org/0000-0001-8168-1538)
- Shuai Zhao (ORCID: https://orcid.org/0009-0007-0006-8987)
- Aaron Johnston (ORCID: https://orcid.org/0000-0002-7836-4221)
Institutions
- Baylor College of Medicine (US)
- University of Oxford (GB)
Publication Details
- Journal
- The Journal of Cardiovascular Aging
- Published
- 2024-11-07
- DOI
- https://doi.org/10.20517/jca.2024.12
- Citations
- 6
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.41
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- National Institutes of Health
- NIHR Oxford Biomedical Research Centre