RNF13 protects neurons against ischemia-reperfusion injury via stabilizing p62-mediated Nrf2/HO-1 signaling pathway
RNF13 is a crucial regulator of cerebral I/R injury that plays its role in inhibiting cell apoptosis and inflammatory response by preventing the autophagy-medicated degradation of the p62/Nrf2/HO-1 signaling pathway via blocking the interaction of TRIM21-p62 complex. Therefore, RNF13 represents a potential pharmacological target in acute ischemia stroke therapy.
Authors
- Youfan Ye (ORCID: https://orcid.org/0000-0003-3136-8353)
- Qiangping Wang (ORCID: https://orcid.org/0000-0002-9728-4075)
- Baoping Zheng (ORCID: https://orcid.org/0000-0003-4294-1442)
- Shuang Li (ORCID: https://orcid.org/0000-0002-0788-5855)
- Haijun Wang (ORCID: https://orcid.org/0000-0003-0598-6457)
- Wenjie Wu (ORCID: https://orcid.org/0000-0001-5888-1208)
- Xiaobing Jiang (ORCID: https://orcid.org/0000-0001-6870-1020)
- Zhen Liu (ORCID: https://orcid.org/0000-0002-1401-9621)
- Wenke Zhou (ORCID: https://orcid.org/0000-0003-0455-2809)
- Fangcheng Zhang (ORCID: https://orcid.org/0000-0002-9376-4944)
- Kaixuan Yan
- Lanlan Yan
Institutions
- Wuhan University (CN)
- First Affiliated Hospital of Xinxiang Medical University (CN)
- Renmin Hospital of Wuhan University (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1186/s12964-024-01905-2
- Citations
- 11
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.59
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province