Model-based characterization of total serum bilirubin dynamics in preterm infants
The study characterizes the natural dynamics of total serum bilirubin in preterm infants (24-32 weeks' gestation) using a patient-specific exponential decay model. The model describes patient-specific patterns of TSB evolution from day three to the first weeks, providing a median [IQR] root-mean-squared error of 8.74 [4.89, 14.25] µmol/L. Complementary to previous studies focusing on the first 72-96 h, our study emphasizes the later decay course, contributing to a comprehensive long-term characterization of the natural TSB dynamics in preterm infants. The proposed model holds potential for clinical decision support systems for the optimization of NICU monitoring and high-risk event detection.
Authors
- Alfredo Hernández (ORCID: https://orcid.org/0000-0003-0765-2311)
- Géraldine Gascoin (ORCID: https://orcid.org/0000-0001-5898-9622)
- Emmanuelle Levine
- Alain Beuchée (ORCID: https://orcid.org/0000-0003-0064-7085)
- Meng Chen (ORCID: https://orcid.org/0000-0002-2449-5904)
- Laurent Storme
Institutions
- Inserm (FR)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Laboratoire Traitement du Signal et de l'Image (FR)
- Centre Hospitalier Universitaire d'Angers (FR)
- Centre Hospitalier Universitaire de Rennes (FR)
- Université d'Angers (FR)
- Université de Rennes (FR)
Publication Details
- Journal
- Pediatric Research
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1038/s41390-024-03644-z
- Citations
- 3
- Primary Topic
- Neonatal Health and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 3.33
Funders
- China Scholarship Council
- Centre Hospitalier Universitaire de Rennes