Design, Synthesis, and Antitumor Potential of New Thiazolecontained 5-Fluoro-2-Oxindole Derivatives as Sunitinib Analogues
Compound 3g demonstrated high <i>in vitro</i> NCI-60 anticancer activity against nine cancer types and showed cell growth inhibition against leukemia, CNS, and breast cancer at 6 - 31% higher than Sunitinib, and may represent the basis for further modification of the thiazole-containing analogs of the anticancer drug Sunitinib.
Authors
- В. С. Броварец (ORCID: https://orcid.org/0000-0001-6668-3412)
- Oleksandr Kobzar (ORCID: https://orcid.org/0000-0003-4370-7041)
- Victor V. Zhirnov (ORCID: https://orcid.org/0000-0001-7453-7124)
- Л. М. Потиха (ORCID: https://orcid.org/0000-0002-7632-9246)
- Ivan Semenyuta (ORCID: https://orcid.org/0000-0001-8464-3692)
- Oleksandr V. Los
- V. O. Sinenko
Institutions
- Taras Shevchenko National University of Kyiv (UA)
- Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar (UA)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2024-11-08
- DOI
- https://doi.org/10.2174/0109298673346427241016100726
- Citations
- 2
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- Enamine
- National Cancer Institute