Primary cortical cell tri-culture to study effects of amyloid-β on microglia function and neuroinflammatory response
The results suggest that neuron-astrocyte-microglia interactions influence microglia function and highlight the utility of the tri-culture model for studies of neuroinflammation, neurodegeneration, and cell-cell communication.
Authors
- Min Zhao (ORCID: https://orcid.org/0000-0002-2500-3035)
- Noah Goshi (ORCID: https://orcid.org/0000-0002-3222-1022)
- Pamela J. Lein (ORCID: https://orcid.org/0000-0001-7665-7584)
- Kan Zhu (ORCID: https://orcid.org/0000-0002-1146-8130)
- Ana Cristina Grodzki (ORCID: https://orcid.org/0000-0002-3500-5309)
- Erkin Şeker (ORCID: https://orcid.org/0000-0003-2401-3562)
- Bryan Le (ORCID: https://orcid.org/0009-0001-9619-5791)
- Hyehyun Kim (ORCID: https://orcid.org/0000-0001-6033-1387)
Institutions
- University of California, Davis (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1177/13872877241291142
- Citations
- 7
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.73
Funders
- National Science Foundation
- National Institutes of Health
- University of California, Davis
- National Institute on Aging
- National Eye Institute
- National Institute of Neurological Disorders and Stroke
- National Institute of Environmental Health Sciences
- National Institute of Biomedical Imaging and Bioengineering
- Division of Materials Research