OFF-LABEL USE OF MIRTAZAPINE FOR MANAGEMENT OF POLYSYMPTOMATOLOGY IN ADVANCED CANCER PATIENTS—A CASE SERIES

Patients suffering with advanced cancer are polysymptomatic, thus for relieving symptoms, they generally receive many medications. Frequently seen symptoms include loss of weight, loss of appetite, anorexia, depression, nausea, vomiting and delirium. Polymedication raises the chances of interactions of drug and its side effects in case of this multimorbid and frail population. Mirtazapine is increasingly utilized as an off-label treatment of polysymptoms like loss of appetite, anxiety, depression, nausea and insomnia. The following case reports will highlight the potential benet of off-label mirtazapine use for polysymptomatology management in advanced cancer patients.