Diet Mediate the Impact of Host Habitat on Gut Microbiome and Influence Clinical Indexes by Modulating Gut Microbes and Serum Metabolites
The impact of external factors on the human gut microbiota and how gut microbes contribute to human health is an intriguing question. Here, the gut microbiome of 3,224 individuals (496 with serum metabolome) with 109 variables is studied. Multiple analyses reveal that geographic factors explain the greatest variance of the gut microbiome and the similarity of individuals' gut microbiome is negatively correlated with their geographic distance. Main food components are the most important factors that mediate the impact of host habitats on the gut microbiome. Diet and gut microbes collaboratively contribute to the variation of serum metabolites, and correlate to the increase or decrease of certain clinical indexes. Specifically, systolic blood pressure is lowered by vegetable oil through increasing the abundance of Blautia and reducing the serum level of 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1), but it is reduced by fruit intake through increasing the serum level of Blautia improved threonate. Besides, aging-related clinical indexes are also closely correlated with the variation of gut microbes and serum metabolites. In this study, the linkages of geographic locations, diet, the gut microbiome, serum metabolites, and physiological indexes in a Chinese population are characterized. It is proved again that gut microbes and their metabolites are important media for external factors to affect human health.
Authors
- Jing Bai (ORCID: https://orcid.org/0000-0001-6734-296X)
- Mengfan Zhi
- Shufa Du (ORCID: https://orcid.org/0000-0003-1156-0866)
- Wenwen Du (ORCID: https://orcid.org/0000-0002-4476-2985)
- Jiguo Zhang (ORCID: https://orcid.org/0000-0003-3266-8999)
- Yifei Ouyang (ORCID: https://orcid.org/0000-0002-9092-8165)
- Hongru Jiang (ORCID: https://orcid.org/0000-0002-0747-6111)
- Feifei Huang (ORCID: https://orcid.org/0000-0002-7496-4908)
- Qiang Feng (ORCID: https://orcid.org/0000-0002-4055-226X)
- Tianyong Sun
- Meihui Li
- Xiaofan Zhang (ORCID: https://orcid.org/0009-0004-8713-2811)
- Li Li (ORCID: https://orcid.org/0000-0003-2342-3658)
- Bing Zhang (ORCID: https://orcid.org/0000-0002-3377-0963)
- Huijun Wang (ORCID: https://orcid.org/0000-0002-8064-4564)
- Zhihong Wang
- Pingping Wang (ORCID: https://orcid.org/0000-0001-8888-8005)
- Chang Su (ORCID: https://orcid.org/0000-0002-5859-1486)
- Xiaofang Jia (ORCID: https://orcid.org/0000-0002-7127-0011)
- Yanli Wei
- Houbao Qi
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- UNC Libraries
- Published
- 2024-11-06
- DOI
- https://doi.org/10.17615/wbjb-fx59
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- Fogarty International Center
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Carolina Population Center, University of North Carolina at Chapel Hill