A novel hypoxia- and lactate metabolism-related prognostic signature to characterize the immune landscape and predict immunotherapy response in osteosarcoma
Our research has developed a robust hypoxia- and lactate metabolism-related gene signature, providing a solid theoretical foundation for prognosis prediction, classification of "cold" and "hot" tumors, accessing immunotherapy response, and directing personalized treatment for osteosarcoma.
Authors
- Jiyuan Zhu
- Yang Liu (ORCID: https://orcid.org/0000-0001-5752-5180)
- Yizhuo Wang (ORCID: https://orcid.org/0000-0002-1870-0019)
- Xin Wei Wang (ORCID: https://orcid.org/0000-0001-9735-606X)
- Jiayuan Xu (ORCID: https://orcid.org/0009-0006-8377-9831)
- Zheng Yu-fu
- Qi Quan (ORCID: https://orcid.org/0000-0003-1493-4042)
Institutions
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-06
- DOI
- https://doi.org/10.3389/fimmu.2024.1467052
- Citations
- 10
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.40