The proteomic landscape of extracellular vesicles derived from human intervertebral disc cells
Our findings indicate that EVs from IVD cells from tissue with different degrees of degeneration share a majority of the cargo proteins. However, the level of expression differs with degeneration grade. Cargo from the mildly-degenerate samples exhibits the most differences. A better understanding of changes in EV cargo in the degenerative process may provide novel information related to molecular mechanisms underlying IVD degeneration and suggest new potential treatment modalities for IVD-related LBP.
Authors
- Aiwei Sun
- Rakan Bokhari (ORCID: https://orcid.org/0000-0003-4157-1830)
- Lisbet Haglund (ORCID: https://orcid.org/0000-0002-1288-2149)
- Hosni Cherif (ORCID: https://orcid.org/0000-0002-0703-3898)
- Miltiadis Georgiopoulos (ORCID: https://orcid.org/0000-0001-8656-1412)
- Jean Ouellet (ORCID: https://orcid.org/0000-0003-0092-4935)
- Li Li (ORCID: https://orcid.org/0000-0001-6342-0633)
- Hadil Al‐Jallad
- Peter Jarzem
Institutions
- King Abdulaziz University (SA)
- McGill University Health Centre (CA)
- Shriners Hospitals for Children - Canada (CA)
- McGill University (CA)
Publication Details
- Journal
- JOR Spine
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1002/jsp2.70007
- Citations
- 5
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Canadian Institutes of Health Research