Acute depletion of complement <scp>C3</scp> with cobra venom factor attenuates memory deficits induced by status epilepticus
A long-lasting seizure, known as status epilepticus (SE), can raise the chance of having more seizures in the future and can lead to memory problems. While the exact reasons for these issues are not completely known, it is believed that brain inflammation might be involved. In this study, we show that the activation of the body's immune response, especially a part called the C3 component, plays a role in the memory problems that occur after an episode of SE.
Authors
- Nicole D. Schartz (ORCID: https://orcid.org/0000-0003-0590-8854)
- Alexandra L. Sommer
- Amy L. Brewster (ORCID: https://orcid.org/0000-0002-3677-410X)
- Yibo Li (ORCID: https://orcid.org/0000-0002-9640-4493)
Institutions
- Southern Methodist University (US)
- Purdue University West Lafayette (US)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1002/epi4.13030
- Citations
- 5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.24
Funders
- Purdue Research Foundation
- Southern Methodist University
- National Institute of Neurological Disorders and Stroke