Acute depletion of complement <scp>C3</scp> with cobra venom factor attenuates memory deficits induced by status epilepticus

A long-lasting seizure, known as status epilepticus (SE), can raise the chance of having more seizures in the future and can lead to memory problems. While the exact reasons for these issues are not completely known, it is believed that brain inflammation might be involved. In this study, we show that the activation of the body's immune response, especially a part called the C3 component, plays a role in the memory problems that occur after an episode of SE.

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Publication Details

Journal
Epilepsia Open
Published
2024-11-05
DOI
https://doi.org/10.1002/epi4.13030
Citations
5
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
1.24

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article

Acute depletion of complement C3 with cobra venom factor attenuates memory deficits induced by status epilepticus

Nicole D. Schartz, Alexandra L. Sommer, Amy L. Brewster, Yibo Li
5 citations
Epilepsia Open
Neuroinflammation and Neurodegeneration Mechanisms
1.24
article

Acute depletion of complement C3 with cobra venom factor attenuates memory deficits induced by status epilepticus

Nicole D. Schartz, Alexandra L. Sommer, Amy L. Brewster, Yibo Li
article en
5 citations

Abstract

A long-lasting seizure, known as status epilepticus (SE), can raise the chance of having more seizures in the future and can lead to memory problems. While the exact reasons for these issues are not completely known, it is believed that brain inflammation might be involved. In this study, we show that the activation of the body's immune response, especially a part called the C3 component, plays a role in the memory problems that occur after an episode of SE.

Epilepsia OpenVol. 9(6)
Southern Methodist University (US), Purdue University West Lafayette (US)
Purdue Research Foundation, Southern Methodist University, National Institute of Neurological Disorders and Stroke
Good health and well-being
Openalex Percentile: Top 20%
Neuroinflammation and Neurodegeneration Mechanisms
1.24
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Acute depletion of complement <scp>C3</scp> with cobra venom factor attenuates memory deficits induced by status epilepticus — Nicole D. Schartz, Alexandra L. Sommer, et al. · Epilepsia Open (2024) | TGRS Research Map | TGRS