Exploring the relationship between cathepsin and age-related macular degeneration using Mendelian randomization
This study demonstrated a potential link between the cathepsin family and the onset of AMD. Elevated serum concentrations of cathepsin L2 may serve as a protective factor for atrophic AMD, while increased levels of serum cathepsin G and O concentrations may promote the development of exudative AMD. Besides, the development of AMD may be associated with elevated serum concentrations of cathepsin E.
Authors
- Qiuyuan Wang (ORCID: https://orcid.org/0000-0002-1464-5243)
- Shanjun Cai (ORCID: https://orcid.org/0000-0002-5900-9881)
Institutions
- Zunyi Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-11-06
- DOI
- https://doi.org/10.3389/fmed.2024.1460779
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00