Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy

In the case of similar unbound paclitaxel concentration in the plasma of patients and assumed species-independent extent of paclitaxel transport across the barriers, nab- and micellar-PTX formulations can lead to higher paclitaxel exposure at CIPN-sites in comparison to CreEL-PTX.

Authors

Irena Loryan (ORCID: https://orcid.org/0000-0002-1557-4416)
Yang Hu (ORCID: https://orcid.org/0000-0002-8702-6654)
Margareta Hammarlund‐Udenaes (ORCID: https://orcid.org/0000-0002-9181-1321)
Milda Girdenyté (ORCID: https://orcid.org/0000-0002-3701-3847)
Aghavni Ginosyan

Institutions

Uppsala University (SE)
Vilnius University (LT)

Publication Details

Journal: Frontiers in Pharmacology
Published: 2024-11-06
DOI: https://doi.org/10.3389/fphar.2024.1486686
Citations: 7
Primary Topic: Cancer Treatment and Pharmacology
Type: article
Field-Weighted Citation Impact: 1.98

Funders

Vetenskapsrådet
Innovative Medicines Initiative

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article

Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy

Irena Loryan, Yang Hu, Margareta Hammarlund‐Udenaes, Milda Girdenyté et al.

Nov 6, 2024

7 citations

Frontiers in Pharmacology

Cancer Treatment and Pharmacology

1.98

article

Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy

Irena Loryan, Yang Hu, Margareta Hammarlund‐Udenaes, Milda Girdenyté, Aghavni Ginosyan

November 6, 2024article en

7 citations

Abstract

In the case of similar unbound paclitaxel concentration in the plasma of patients and assumed species-independent extent of paclitaxel transport across the barriers, nab- and micellar-PTX formulations can lead to higher paclitaxel exposure at CIPN-sites in comparison to CreEL-PTX.

Frontiers in PharmacologyVol. 15

Uppsala University (SE), Vilnius University (LT)

Vetenskapsrådet, Innovative Medicines Initiative

Openalex Percentile: Top 11%

Cancer Treatment and Pharmacology

1.98

DOI Open Access PDF OpenAlex

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Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy — Irena Loryan, Yang Hu, et al. · Frontiers in Pharmacology (2024) | TGRS Research Map | TGRS