Exposure to the antiretroviral drug dolutegravir impairs structure and neurogenesis in a forebrain organoid model of human embryonic cortical development
Together, these results illustrate the potential for human iPSC-based strategies to reveal biological processes during neurogenesis that may be affected by therapeutic drugs and provide complementary data in relevant human cell types to augment preclinical investigations of drug safety during pregnancy.
Authors
- Guo‐li Ming (ORCID: https://orcid.org/0000-0002-2517-6075)
- Hongjun Song (ORCID: https://orcid.org/0000-0002-8720-5310)
- Daniel Y. Zhang (ORCID: https://orcid.org/0000-0001-9962-9295)
- Yijing Su (ORCID: https://orcid.org/0000-0002-4146-0068)
- Cagla Akay (ORCID: https://orcid.org/0000-0003-0199-3836)
- Yusha Sun (ORCID: https://orcid.org/0000-0003-4835-3000)
- Kelly L. Jordan‐Sciutto (ORCID: https://orcid.org/0000-0002-0827-1337)
- Kimberly M. Christian (ORCID: https://orcid.org/0000-0003-4315-6710)
- Alessandra Angelucci (ORCID: https://orcid.org/0000-0002-1957-2231)
- Emma LaNoce
- Alan Garcia-Epelboim (ORCID: https://orcid.org/0000-0002-0414-8331)
- Giana Alepa
Institutions
- California Institute for Regenerative Medicine (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2024-11-06
- DOI
- https://doi.org/10.3389/fnmol.2024.1459877
- Citations
- 2
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- National Institutes of Health