The potential role of CGRP in synuclein-associated neurodegenerative disorders
In this hypothesis article, the potential clinicopathological associations of Calcitonin Gene Related Peptide (CGRP) with the development of synuclein-associated neurodegenerative disorders (SAND) are discussed. The presence of <i>α</i>-syn and CGRP in the CNS and the ENS and the intricate role of CGRP and its related pathways in inflammation, apoptosis, metabolism, neuromodulation, and brain-gut communication are analyzed. Since this hypothesis is confirmed, modulating CGRP-potential related pathways may lead to novel disease-modifying therapies.
Authors
- Elissaios Karageorgiou (ORCID: https://orcid.org/0000-0001-9628-6370)
- Athanasia Alexoudi (ORCID: https://orcid.org/0000-0002-8137-8253)
- Vincenzo Donadio
Institutions
- Neurological Institute of Athens (GR)
- Institute of Neurological Sciences (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2024-11-06
- DOI
- https://doi.org/10.3389/fnins.2024.1479830
- Citations
- 4
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.48