A new isoflavone from processed root barks of <i>Paeonia suffruticosa</i> and their procoagulant activity
One new isoflavone, 6'-dihydroxy-2-methyl-2'-methoxyl-3'-acetylisoflavone (<b>1</b>) and six known compounds (<b>2</b>-<b>7</b>) were isolated from the processed root barks of <i>Paeonia suffruticosa</i>. The structures of these compounds were elucidated using UV, IR, NMR, and HR-ESI-MS data. Compound <b>1</b> represents the first example of naturally occurring 2-substituted isoflavone. Compounds <b>2</b>-<b>7</b> were isolated from the processed root barks of <i>P. suffruticosa</i> for the first time. In addition, all of the compounds were screened for their procoagulant activity. As a result, compounds <b>4</b>, <b>6</b>, and <b>7</b> showed significantly <i>in vitro</i> procoagulant activity.
Authors
- Jiang Meng (ORCID: https://orcid.org/0000-0001-6821-0897)
- Shuo‐Guo Li (ORCID: https://orcid.org/0000-0003-3149-8916)
- Mei Lü (ORCID: https://orcid.org/0000-0001-9236-5418)
- Shumei Wang (ORCID: https://orcid.org/0009-0008-0276-9792)
- Rui Yang (ORCID: https://orcid.org/0000-0001-5495-0165)
Institutions
- Guangdong Pharmaceutical University (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Sichuan Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1080/14786419.2024.2425044
- Citations
- 1
- Primary Topic
- Biological Stains and Phytochemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- National Natural Science Foundation of China