Gene expression of tight junctions in foreskin is not affected by HIV pre-exposure prophylaxis
TJs can limit viral entry into target cells; to affect this biological function viruses can reduce the expression of TJ proteins. Our study, on the expression and regulation of TJs in the foreskin, contribute important knowledge for PrEP safety and further design of HIV-1 prophylaxis.
Authors
- Carolina Herrera (ORCID: https://orcid.org/0000-0003-3701-752X)
- Pontiano Kaleebu (ORCID: https://orcid.org/0000-0001-9706-2977)
- Jennifer Serwanga (ORCID: https://orcid.org/0000-0002-6672-3688)
- Andrew Sentoogo Ssemata (ORCID: https://orcid.org/0000-0003-0060-0842)
- Stefan Petkov (ORCID: https://orcid.org/0000-0002-8052-9646)
- Emily L. Webb (ORCID: https://orcid.org/0000-0002-4019-7456)
- Julie Fox (ORCID: https://orcid.org/0000-0002-0583-8019)
- Thabiso Seiphetlo (ORCID: https://orcid.org/0009-0009-4162-1624)
- Patricia Namubiru (ORCID: https://orcid.org/0000-0003-0320-874X)
- Susan Mugaba
- Limakatso Lebina (ORCID: https://orcid.org/0000-0001-6825-0573)
- Saye Khoo (ORCID: https://orcid.org/0000-0002-2769-0967)
- Clive M. Gray (ORCID: https://orcid.org/0000-0002-9293-901X)
- Geoffrey Odoch
- Francesca Chiodi (ORCID: https://orcid.org/0000-0002-1385-8343)
- Daniel Opoka
- Neil Alexander Martinson (ORCID: https://orcid.org/0000-0002-0184-5705)
- Azure-Dee Pillay
- Laura Else
- Heejin Yun (ORCID: https://orcid.org/0000-0003-0435-7253)
Institutions
- University of Liverpool (GB)
- King's College London (GB)
- University of the Witwatersrand (ZA)
- Stellenbosch University (ZA)
- Karolinska Institutet (SE)
- London School of Hygiene & Tropical Medicine (GB)
- Perinatal HIV Research Unit (ZA)
- Imperial College London (GB)
- Medical Research Council (GB)
- Uganda Virus Research Institute (UG)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-06
- DOI
- https://doi.org/10.3389/fimmu.2024.1415475
- Primary Topic
- Genital Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Imperial College London
- European Commission
- Karolinska Institutet
- Vetenskapsrådet
- Medical Research Council
- European and Developing Countries Clinical Trials Partnership