Identification of Cellular Senescence-Related Critical Genes and Molecular Classification and Revealing the Drug-Resistant Therapeutic Effect of IGFBP2 in Chronic Myeloid Leukemia
Our study conducted a comprehensive analysis on CSRG expression characteristics in CML and explored potential correlations between cellular senescence and immune function. The identification of molecular subtypes provides valuable insights into assessing individual patients' biological characteristics for guiding clinical treatment decisions. Additionally, IGFBP2 has emerged as a promising therapeutic target for therapy-resistant cases of CML.
Authors
- Jing Liu (ORCID: https://orcid.org/0000-0002-3311-0818)
- Xiaolin Li (ORCID: https://orcid.org/0000-0002-7510-9735)
- Xiaozhong Wang (ORCID: https://orcid.org/0000-0001-8152-8971)
- Yanmei Xu
- Bo Huang (ORCID: https://orcid.org/0000-0001-6668-671X)
- Fangyi Yao
- Fangmin Zhong
- Wentao Yang (ORCID: https://orcid.org/0000-0002-7344-496X)
- Zi-Hao Wang (ORCID: https://orcid.org/0000-0001-6368-2158)
Institutions
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/jir.s483705
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province