Population-Specific Predictors of Immunologic Reconstitution Following Initiation of Combined Antiretroviral Therapy in Children: A Retrospective Observational Study from a 15-Year Cohort of HIV-Positive Children and Adolescents in Eritrea
The study underscores the interplay of baseline CD4 count, gender, and regimen choice in shaping the effectiveness of cART in children. Lower baseline absolute CD4 count was associated with IR after starting cART. Notably, children on EFV had a higher likelihood of inadequate IR after 6 months, and male children were more prone to insufficient IR at 12 months. Targeting these population-specific factors may be pivotal in advancing gender-responsive therapeutic strategies and improving health outcomes for HIV-infected children in sub-optimal clinical settings and resource-constrained environments.
Authors
- Samuel Tekle Mengistu (ORCID: https://orcid.org/0000-0002-2817-1421)
- Awet Ghebreberhan Mehretab (ORCID: https://orcid.org/0000-0002-6543-8754)
- Habtemichael M. Teklemariam (ORCID: https://orcid.org/0000-0003-2961-8165)
- Ghirmay Ghebrekidan Ghebremeskel (ORCID: https://orcid.org/0000-0002-0275-2279)
- Misgana Teklehaimanot Tsegai
- Henok Afewerki Kidane
- Yonas Tesfagabr Abraham (ORCID: https://orcid.org/0009-0000-6788-5788)
- Robel Afeworki Habte (ORCID: https://orcid.org/0000-0001-9220-004X)
Institutions
- American Bar Association (US)
- Adan Hospital (KW)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- African Population and Health Research Center (KE)
- Ministry of Health (KW)
- Ministerio de Salud (SV)
- University of Asmara (ER)
Publication Details
- Journal
- HIV/AIDS - Research and Palliative Care
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/hiv.s483094
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00