The association between metabolite profiles and impaired bone microstructure in adult growth hormone deficient rats
Adult dw/dw rats exhibit impaired bone microstructure and distinct serum metabolic profiles, and the altered metabolites were significantly associated with bone microstructure destruction. This provides a new insight into understanding the mechanism of bone deterioration in AGHD patients from a metabolic perspective.
Authors
- Hanyuan Xu
- Xiaorui Lyu (ORCID: https://orcid.org/0000-0002-6523-4292)
- Yu Wan (ORCID: https://orcid.org/0000-0002-6723-1490)
- Hongbo Yang (ORCID: https://orcid.org/0000-0003-1694-9352)
- Huijuan Zhu (ORCID: https://orcid.org/0000-0001-5172-6870)
- Fengying Gong (ORCID: https://orcid.org/0000-0002-6361-3811)
- Wenjing Hu (ORCID: https://orcid.org/0000-0002-8927-2445)
- Hui Pan (ORCID: https://orcid.org/0000-0003-2413-0646)
- Xiaonan Guo
- Shanshan Liu (ORCID: https://orcid.org/0000-0003-0533-933X)
- Linjie Wang (ORCID: https://orcid.org/0000-0002-9548-0398)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Wuhan University (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1186/s12891-024-08010-y
- Citations
- 1
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.36
Funders
- National Natural Science Foundation of China
- Peking Union Medical College Hospital
- Peking Union Medical College
- National Health Commission of the People's Republic of China