Mechanochemically facilitated silver-catalyzed direct H/D exchange on heteroarenes
Despite recent advances in H/D exchange, the effective deuteration of polyarenes remains challenging, due to their insolubility and hydrophobicity. This study presents a concept proofing of a mechanochemically facilitated direct H/D exchange. The silver-catalyzed deuteration of heteroarenes was promoted smoothly within 99 minutes of grinding, with heavy water as the deuterium source.
Authors
- Kenan Wang
- Jian‐Fei Bai (ORCID: https://orcid.org/0000-0002-9128-5819)
- Zhanghua Gao (ORCID: https://orcid.org/0000-0002-6950-8609)
- Yifeng Han (ORCID: https://orcid.org/0000-0002-6247-0708)
- Zhi‐Jiang Jiang (ORCID: https://orcid.org/0000-0003-2323-1840)
- Jia Chen (ORCID: https://orcid.org/0000-0003-1541-2617)
- Yun Jia (ORCID: https://orcid.org/0000-0001-6244-2670)
- Jiawei Han (ORCID: https://orcid.org/0009-0002-6646-2753)
- Si-Han Xu
Institutions
- Zhejiang Sci-Tech University (CN)
- Ningbo University of Technology (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1039/d4ob01581a
- Citations
- 4
- Primary Topic
- Chemical Reactions and Isotopes
- Type
- article
- Field-Weighted Citation Impact
- 0.83