Dynamics of cell-free tumor DNA correlate with early MRI response during chemoradiotherapy in rectal cancer
Weekly measurement of ctDNA during radiochemotherapy is feasible and might represent a promising biomarker. Bigger initial primary tumors showed different ctDNA shedding profiles compared with smaller primary tumors and correlations of ctDNA dynamics with early imaging response were found.
Authors
- Olga Kelemen
- Irina Bonzheim (ORCID: https://orcid.org/0000-0002-7732-0788)
- Cihan Gani (ORCID: https://orcid.org/0000-0003-0242-9428)
- Michael Orth (ORCID: https://orcid.org/0000-0002-4608-7151)
- Olaf Rieß (ORCID: https://orcid.org/0000-0002-7011-1369)
- Maximilian Niyazi (ORCID: https://orcid.org/0000-0002-7711-9486)
- Stephan Clasen
- Stephan Ossowski (ORCID: https://orcid.org/0000-0002-7416-9568)
- Leon Schuetz
- Christopher Schroeder
- Kerstin Clasen
- Nadja Ballin
Institutions
- University Children's Hospital Tübingen (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1186/s13014-024-02540-4
- Citations
- 3
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.86
Funders
- Eberhard Karls Universität Tübingen
- Universitätsklinikum Tübingen