Exploring the Role of Inflammatory Genes and Immune Infiltration in Vestibular Schwannomas Pathogenesis
Our study underscores the role of inflammation in VS pathogenesis, showing that macrophage activation with M2 polarization and the expression of inflammatory cytokines, especially IL-10/IL-10RA and IL-18, are linked to tumor size and auditory function. This study highlights the inflammatory landscape's impact on VS behaviors, providing a basis for targeted therapeutic strategies.
Authors
- Jinlu Gan
- Deqiang Lei (ORCID: https://orcid.org/0000-0002-3012-0033)
- Hongyang Zhao (ORCID: https://orcid.org/0009-0008-2619-3716)
- Yanling Zhang (ORCID: https://orcid.org/0000-0002-7327-8631)
- Lei Wang (ORCID: https://orcid.org/0000-0002-3368-2832)
- Yingchun Zhou (ORCID: https://orcid.org/0000-0003-1340-113X)
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/jir.s476745
- Citations
- 5
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 1.93