Exosomes derived from Umbilical cord mesenchymal stem cell promote hair regrowth in C57BL6 mice through upregulation of the RAS/ERK signaling pathway
In this study, we demonstrated the therapeutic effect of umbilical cord MSC-derived exosomes on androgenetic alopecia and verified that exosomes regulate hair follicle stem cell stemness through the RAS/ERK pathway to promote hair proliferation and thus hair growth in mice with androgenetic alopecia, providing a potential therapeutic strategy for androgenetic alopecia.
Authors
- Wenbo Meng (ORCID: https://orcid.org/0000-0002-9355-0225)
- Xuekai Hu (ORCID: https://orcid.org/0000-0001-5049-4377)
- Pinyan Liu (ORCID: https://orcid.org/0000-0002-7620-9076)
- Jiayun Wei
- Yongcui Mao
- Qiuxia Zheng (ORCID: https://orcid.org/0000-0003-2415-7064)
- Jia Yao (ORCID: https://orcid.org/0000-0002-0811-8287)
- Ye Xie
Institutions
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Translational Internal Medicine
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1515/jtim-2024-0012
- Citations
- 20
- Primary Topic
- Hair Growth and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 10.70