Sphingosine-1-phosphate alleviates Sjögren’s syndrome-like symptoms via inducing autophagy and regulating status of Treg cells in NOD mice
S1P therapy alleviated SS-like symptoms in NOD mice by increasing the number of Treg cells, by restoring Treg cell function, and by positively regulating autophagy via crosstalk. Such therapy may be a new and valuable SS treatment option.
Authors
- Lei Sun (ORCID: https://orcid.org/0000-0003-0141-2093)
- Xiaojie Ni (ORCID: https://orcid.org/0000-0002-8903-4834)
- JiaHui Xue
- Chong Gao (ORCID: https://orcid.org/0000-0001-7639-0808)
- Lei Qiang (ORCID: https://orcid.org/0000-0002-7164-3164)
- Yue Jin (ORCID: https://orcid.org/0000-0002-9452-3253)
- Yanlin Wang (ORCID: https://orcid.org/0000-0002-6908-1529)
- Jing Luo (ORCID: https://orcid.org/0000-0002-1242-0286)
- Min Feng (ORCID: https://orcid.org/0000-0002-4068-8511)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Shanxi Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1016/j.intimp.2024.113514
- Citations
- 6
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 1.96