Causal Correlations Between Inflammatory Proteins and Heart Failure: A Two-Sample Mendelian Randomization Analysis
This study provides genetically supported evidence of the causal association of specific inflammatory proteins with HF risk. The positive association of MMP-1 and TNF-beta with HF suggests their roles in disease pathogenesis, whereas the inverse association of the uPA indicates its potential protective effect. Our findings highlight the potential of targeting specific inflammatory pathways as a therapeutic strategy for HF.
Authors
- Rui Qiao
- Xuejun Xiang
- Yue Peng (ORCID: https://orcid.org/0009-0002-3840-7677)
- Xian‐He Lin
- Xian‐Guan Zhu (ORCID: https://orcid.org/0000-0001-9480-8120)
- Yuanxi Zheng
- Geoffrey Liu (ORCID: https://orcid.org/0000-0002-2603-7296)
- Liling Zhang (ORCID: https://orcid.org/0000-0002-0198-2603)
- Lidong Chen (ORCID: https://orcid.org/0000-0002-9683-037X)
- Xianjin Wang (ORCID: https://orcid.org/0000-0001-9117-3844)
Institutions
- Wannan Medical College (CN)
- Anhui Medical University (CN)
- Anqing City Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1002/ehf2.15151
- Citations
- 3
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.65
Funders
- Anhui Medical University