COVID-19 vaccination-related delayed adverse events among people with rheumatoid arthritis: results from the international COVAD survey

This study aimed to assess COVID-19 vaccination-related AEs in patients with rheumatoid arthritis (RA), in the COVID-19 Vaccination in Autoimmune Diseases (COVAD)-2 study. An online international cross-sectional survey captured self-reported data on COVID-19 vaccination-related adverse events (AEs) in people with RA, autoimmune diseases (AIDs; rheumatic [r] and non-rheumatic [nr]) and healthy controls (HCs). The survey was circulated by the COVAD study group, comprising 157 collaborators across 106 countries, from February to June 2022. Delayed AEs among RA were compared with other rAIDs, nrAIDs and HCs using multivariable binary regression. A total of 7203 participants were included (1423 [19.7%] RA, 2620 [36.4%] rAIDs, 426 [5.9%] nrAIDs, 2734 [38%] HCs), with 75% female. Compared to HCs, individuals with RA reported higher overall major AEs [OR 1.3 (1.0-1.7)], and an increased number of several minor AEs. Compared to nrAIDs, people with RA had several increased reported minor AEs including myalgia and joint pain. People with active RA had increased major AEs [OR 1.8 (1.1-3.0)] and hospitalisation [OR 4.1 (1.3 - 13.3)] compared to inactive RA. RA patients without autoimmune comorbidities had significantly fewer major and minor AEs than those with other rAIDs. A decreased incidence of hospitalisation was seen in patients taking methotrexate or TNF inhibitors compared to patients not taking these medications. COVID-19 vaccination is associated with minimal to no risks of delayed AEs in patients with RA compared to HCs, and fewer compared to other rAIDs. Active RA and presence of co-existing rAIDs were associated with an increased risk of delayed AEs.

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Journal
Rheumatology International
Published
2024-11-06
DOI
https://doi.org/10.1007/s00296-024-05742-x
Citations
1
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SARS-CoV-2 and COVID-19 Research
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article
Field-Weighted Citation Impact
0.39

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COVID-19 vaccination-related delayed adverse events among people with rheumatoid arthritis: results from the international COVAD survey

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article en
1 citations

Abstract

This study aimed to assess COVID-19 vaccination-related AEs in patients with rheumatoid arthritis (RA), in the COVID-19 Vaccination in Autoimmune Diseases (COVAD)-2 study. An online international cross-sectional survey captured self-reported data on COVID-19 vaccination-related adverse events (AEs) in people with RA, autoimmune diseases (AIDs; rheumatic [r] and non-rheumatic [nr]) and healthy controls (HCs). The survey was circulated by the COVAD study group, comprising 157 collaborators across 106 countries, from February to June 2022. Delayed AEs among RA were compared with other rAIDs, nrAIDs and HCs using multivariable binary regression. A total of 7203 participants were included (1423 [19.7%] RA, 2620 [36.4%] rAIDs, 426 [5.9%] nrAIDs, 2734 [38%] HCs), with 75% female. Compared to HCs, individuals with RA reported higher overall major AEs [OR 1.3 (1.0-1.7)], and an increased number of several minor AEs. Compared to nrAIDs, people with RA had several increased reported minor AEs including myalgia and joint pain. People with active RA had increased major AEs [OR 1.8 (1.1-3.0)] and hospitalisation [OR 4.1 (1.3 - 13.3)] compared to inactive RA. RA patients without autoimmune comorbidities had significantly fewer major and minor AEs than those with other rAIDs. A decreased incidence of hospitalisation was seen in patients taking methotrexate or TNF inhibitors compared to patients not taking these medications. COVID-19 vaccination is associated with minimal to no risks of delayed AEs in patients with RA compared to HCs, and fewer compared to other rAIDs. Active RA and presence of co-existing rAIDs were associated with an increased risk of delayed AEs.

Rheumatology InternationalVol. 44(12)
Southport and Ormskirk Hospital NHS Trust (GB), Ivano-Frankivsk National Medical University (UA), Siriraj Hospital (TH), Karolinska University Hospital (SE), University of Ghana (GH), Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN), Universidade de São Paulo (BR), King's College London (GB), Saint Joseph University (LB), King Edward Memorial Hospital and Seth G.S. Medical College (IN), B. J. Medical College & Sassoon Hospital (IN), Pontificia Universidad Javeriana (CO), Mahidol University (TH), Örebro University (SE), Manchester Academic Health Science Centre (GB), Korle Bu Teaching Hospital (GH), Karolinska Institutet (SE), University of Manchester (GB), Maulana Azad Medical College (IN), Taichung Veterans General Hospital (TW), St. Luke's Medical Center (PH), Hôtel-Dieu de France (LB), King's College Hospital (GB), The Royal Wolverhampton NHS Trust (GB), Wolverhampton Hospital (GB)
Amgen, Eli Lilly and Company, Pfizer, AstraZeneca, Sanofi, Gilead Sciences, Celltrion, Deutsche Gesellschaft für Muskelkranke
Good health and well-being
Openalex Percentile: Top 35%
SARS-CoV-2 and COVID-19 Research
0.39
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