Association and mediation pathways of maternal hyperglycaemia and liability to gestational diabetes with neonatal outcomes: A two‐sample Mendelian randomization study
Maternal hyperglycemia is associated with higher birthweight (possibly indicating macrosomia), mediated via increased placental growth. GDM and T2D liability are related to preterm birth, whilst the association for T2D liability is driven by maternal adiposity.
Authors
- Hugh Simon Lam (ORCID: https://orcid.org/0000-0001-9912-0544)
- Shan Luo (ORCID: https://orcid.org/0000-0003-3368-9935)
- Shiu Lun Au Yeung (ORCID: https://orcid.org/0000-0001-6136-1836)
- Baoting He (ORCID: https://orcid.org/0000-0002-9976-7775)
- Xiu Qiu (ORCID: https://orcid.org/0000-0003-1248-229X)
- Eric A. W. Slob (ORCID: https://orcid.org/0000-0002-1644-0735)
- Songying Shen (ORCID: https://orcid.org/0000-0002-1329-316X)
Institutions
- Chinese University of Hong Kong (HK)
- University of Cambridge (GB)
- MRC Biostatistics Unit (GB)
- University of Hong Kong (HK)
- Erasmus University Rotterdam (NL)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1111/dom.16045
- Citations
- 2
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Health and Medical Research Fund