Outcomes of patients with intermediate‐risk neuroblastoma presenting with motor deficits relating to intraspinal tumor extension: A report from the Children's Oncology Group study ANBL0531
Patients presenting with motor deficits due to intraspinal tumor had excellent survival and favorable neurologic outcomes, with the majority reporting complete resolution of motor symptoms regardless of severity and duration of symptoms at diagnosis or neurosurgical intervention. Prompt diagnosis and initiation of first-line chemotherapy treatment remain priority, while neurosurgical intervention should be reserved for patients with rapid neurologic deterioration. Biology-based therapy and tumor response should continue to be used to maintain favorable outcomes.
Authors
- Arlene Naranjo (ORCID: https://orcid.org/0000-0001-7737-4324)
- Wendy B. London (ORCID: https://orcid.org/0000-0003-3571-6538)
- John M. Maris (ORCID: https://orcid.org/0000-0002-8088-7929)
- Hiroyuki Shimada (ORCID: https://orcid.org/0000-0001-5025-7507)
- Julie Voeller (ORCID: https://orcid.org/0000-0001-7811-513X)
- Julie R. Park (ORCID: https://orcid.org/0000-0002-6777-9165)
- Howard M. Katzenstein (ORCID: https://orcid.org/0000-0002-5314-2972)
- Clare J. Twist
- Susan L. Cohn (ORCID: https://orcid.org/0000-0001-5749-7650)
- Rochelle Bagatell (ORCID: https://orcid.org/0000-0002-5729-8819)
- Michael D. Hogarty (ORCID: https://orcid.org/0000-0002-9221-4852)
- Sheena C. Tenney (ORCID: https://orcid.org/0000-0002-3255-8450)
- Lulu Chen (ORCID: https://orcid.org/0000-0001-9621-9231)
- Michael H. Handler
- Julie Gastier‐Foster
- Mary Lou Schmidt
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- St. Jude Children's Research Hospital (US)
- Lucile Packard Children's Hospital (US)
- Children's Hospital of Philadelphia (US)
- Harvard University (US)
- Baylor College of Medicine (US)
- University of Florida (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- Children's Hospital Colorado (US)
- Children's Oncology Group (US)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
- University of Pennsylvania (US)
- University of Colorado Denver (US)
- Stanford University (US)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1002/pbc.31407
- Citations
- 1
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.37
Funders
- St. Baldrick's Foundation
- National Institutes of Health
- National Cancer Institute