In Silico and In Vitro Investigation of Cytotoxicity and Apoptosis of Acridine/Sulfonamide Hybrids Targeting Topoisomerases I and II
Compounds <b>7c</b> and <b>8b</b> hold promise as potential anticancer drugs due to their anti-proliferative and proapoptotic effects, which are mediated by their action on the topoisomerase enzyme, particularly Topo II.
Authors
- Doaa El-Khateeb
- F E Awadallah
- Reem Binsuwaidan (ORCID: https://orcid.org/0000-0003-1406-282X)
- Elshaymaa I. Elmongy (ORCID: https://orcid.org/0000-0003-1160-5040)
- Husnain Ali
- Yasmine S. Moemen (ORCID: https://orcid.org/0000-0003-3173-7155)
- Ashraf A. Khalil (ORCID: https://orcid.org/0000-0001-5307-241X)
- Ibrahim El Tantawy El Sayed (ORCID: https://orcid.org/0000-0003-1227-7931)
- Mohamed Badr (ORCID: https://orcid.org/0000-0003-3596-1664)
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Menoufia University (EG)
- Helwan University (EG)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-11-06
- DOI
- https://doi.org/10.3390/ph17111487
- Citations
- 5
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Princess Nourah Bint Abdulrahman University