Immunoscore Evaluation in Gastric Adenocarcinoma: Implications for Prognosis and Personalized Immune Therapy

Gastric Adenocarcinoma has a dismal prognosis, prompting the exploration of novel assessment methods. This retrospective study involved 50 gastrectomy specimens to evaluate the Immunoscore System (IS) as an immune status and prognosis predictor. T-cell densities of CD3+ and CD8+ were measured through immunohistochemistry. Correlations with clinicopathological characteristics and survival time were examined. The study did not reveal significant correlations between Immunoscore, tumor characteristics, and survival time, which may be influenced by the advanced stages of disease and unique gastric carcinoma microenvironment. Future research, encompassing biopsies and digital software, may shed more light on IS in gastric cancers. This study's manual immunoscoring method offers a practical and affordable way to assess the immunological state of tumours in different organs, especially during initial diagnostic biopsies that might guide neoadjuvant treatments. In the future, immunoscoring is expected to be very important in the field of personalised immune therapy.