SMN2 gene copy number affects the incidence and prognosis of motor neuron diseases in Japan

Our findings suggest that SMN2 copy number reduction may adversely affect the onset and prognosis of MND, including ALS and LMND, in Japanese.

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Publication Details

Journal
BMC Medical Genomics
Published
2024-11-06
DOI
https://doi.org/10.1186/s12920-024-02026-y
Citations
2
Primary Topic
Neurogenetic and Muscular Disorders Research
Type
article
Field-Weighted Citation Impact
0.88

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article

SMN2 gene copy number affects the incidence and prognosis of motor neuron diseases in Japan

Genki Tohnai, Saori Toyoda, Akio Yokoseki, Akiyoshi Kakita et al.
2 citations
BMC Medical Genomics
Neurogenetic and Muscular Disorders Research
0.88
article

SMN2 gene copy number affects the incidence and prognosis of motor neuron diseases in Japan

Genki Tohnai, Saori Toyoda, Akio Yokoseki, Akiyoshi Kakita, Ryoichi Nakamura, Satoshi Kuwabara, Mari Tada, Tomohiko Ishihara, Ryuji Kaji, Osamu Kano, Sachiko Hirokawa, Yuishin Izumi, Akihide Koyama, Gen Sobue, Yuya Hatano, Kenta Kashiwagi, Masashi Aoki, Mitsuya Morita, Osamu Onodera, Asako Tamura
article en
2 citations

Abstract

Our findings suggest that SMN2 copy number reduction may adversely affect the onset and prognosis of MND, including ALS and LMND, in Japanese.

BMC Medical GenomicsVol. 17(1)
Toho University (JP), Jichi Medical University (JP), Chiba University (JP), Aichi Medical University (JP), Mie University (JP), Tohoku University (JP), Niigata University (JP), Tokushima University (JP)
Japan Agency for Medical Research and Development, Ministry of Education, Culture, Sports, Science and Technology, Ministry of Health, Labour and Welfare, Mitsubishi Tanabe Pharma Corporation, Japan Society for the Promotion of Science
Good health and well-being
Openalex Percentile: Top 23%
Neurogenetic and Muscular Disorders Research
0.88
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