Pleiomorph Sarcome of the Thigh

This article focuses on pleomorphic sarcomas, which are malignant mesenchymal tumors with a complex genetic background underlying their morphological pleomorphism. These are poorly differentiated tumors that can maintain different lines of differentiation, sometimes correlating with clinicopathological or prognostic characteristics. Accurate diagnosis in this group of tumors relies on adequate sampling due to their heterogeneity and evaluation by both microscopy and large immunohistochemistry panels. Molecular analyzes have a limited role in their diagnosis as opposed to translocation-related sarcomas, but they may provide important the anotic and prognostic information in the future