NSUN2 Promotes Head and Neck Squamous Cell Carcinoma Progression by Targeting EMT-Related Gene LAMC2 in an m5C-YBX1-Dependent Manner
NSUN2-mediated m<sup>5</sup>C-modification enhanced LAMC2 stability, promoting epithelial-mesenchymal transition (EMT) signaling pathways. These findings demonstrate that NSUN2 promotes the initiation and progression of HNSCC by stabilizing the LAMC2 transcript through m<sup>5</sup>C-dependent mechanisms, offering a promising epitranscriptomic-targeted therapeutic approach for HNSCC.
Authors
- Dongxiao Tang (ORCID: https://orcid.org/0000-0003-2462-0338)
- Lianlian Liu (ORCID: https://orcid.org/0000-0002-1876-5488)
- Shuojin Huang
- Congyuan Cao (ORCID: https://orcid.org/0009-0005-6300-3166)
- Anxun Wang (ORCID: https://orcid.org/0000-0003-2249-7356)
- Wanhang Zhou
- Qianting He
- Xin Zheng (ORCID: https://orcid.org/0000-0002-4153-8515)
- Yiwen Liu (ORCID: https://orcid.org/0000-0001-6677-7961)
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Biomedicines
- Published
- 2024-11-06
- DOI
- https://doi.org/10.3390/biomedicines12112533
- Citations
- 8
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China