Impairment of regulatory T cell stability in axial spondyloarthritis: role of EZH2 and pSTAT5
By highlighting a deficient expression of EZH2 and pSTAT5 by Treg, we revealed an impaired Treg stability in axSpA. Deciphering the pathways influenced by these molecules is necessary to assess the potential therapeutic benefits of restoring Treg stability in axSpA.
Authors
- Jérôme Biton (ORCID: https://orcid.org/0000-0002-4720-4567)
- Luca Semerano
- Roxane Hervé
- Delphine Lemeiter
- Marie‐Christophe Boissier (ORCID: https://orcid.org/0000-0003-4199-8797)
- Natacha Bessis (ORCID: https://orcid.org/0000-0003-2621-3744)
- Johanna Sigaux (ORCID: https://orcid.org/0000-0002-6371-740X)
- Majda Lyna Mebrek
- Mylène Petit
- Gaëlle Clavel (ORCID: https://orcid.org/0000-0002-5905-9969)
- Magali Breckler
- Tessnime Abaab
Institutions
- Inserm (FR)
- Université Sorbonne Paris Nord (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Fondation de Rothschild (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-06
- DOI
- https://doi.org/10.3389/fimmu.2024.1484321
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- Nord universitet