Single cell RNA-seq reveals cellular and transcriptional heterogeneity in the splenic CD11b+Ly6Chigh monocyte population expanded in sepsis-surviving mice
The splenic CD11b<sup>+</sup>Ly6C<sup>high</sup> myeloid populations expanded in survivors of CLP sepsis correspond to proliferating cells that have an increased metabolic demand and gene signatures consistent with M-MDSCs, a population known to have immunosuppressive capacity.
Authors
- Minakshi Rana (ORCID: https://orcid.org/0000-0003-4817-8767)
- Haruki Watanabe (ORCID: https://orcid.org/0000-0001-7837-086X)
- Kwangmin Choi (ORCID: https://orcid.org/0000-0003-4671-962X)
- Myoungsun Son (ORCID: https://orcid.org/0000-0002-0655-3859)
- Barbara Sherry (ORCID: https://orcid.org/0000-0003-3119-1463)
- Yurong Fei-Bloom
- Pui Yan Chiu
- Betty Diamond (ORCID: https://orcid.org/0000-0002-3250-3804)
Institutions
- Hospital for Special Surgery (US)
- Cincinnati Children's Hospital Medical Center (US)
- Northwell Health (US)
- Feinstein Institute for Medical Research (US)
- Cornell University (US)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1186/s10020-024-00970-0
- Citations
- 10
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- American Association of Immunologists
- Uehara Memorial Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases