Early-life antibiotic exposure aggravate the metabolic dysfunction-associated steatotic liver disease associated hepatocellular carcinoma
Collectively, our findings revealed that early-life antibiotic exposure accelerated the progression of MASLD-HCC by impairing the hepatocytes, immune homeostasis and metabolites persistently, highlighting the importance of the early-life microbiota in the development of MASLD-HCC.
Authors
- Xiaohong Liang (ORCID: https://orcid.org/0000-0002-7626-3478)
- Lifen Gao (ORCID: https://orcid.org/0000-0003-2404-7439)
- Panpan Tian
- Xinyu Tian (ORCID: https://orcid.org/0000-0002-6933-8021)
- Chunhong Ma (ORCID: https://orcid.org/0000-0002-8121-4718)
Institutions
- Shandong University (CN)
- Nanjing Drum Tower Hospital (CN)
- Shandong Special Equipment Inspection Institute (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1186/s12885-024-13136-2
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- National Natural Science Foundation of China
- Nanjing Drum Tower Hospital