Identification of Novel Genetic Loci Affecting Age at Onset of Parkinson's Disease: A Genome‐wide Association Study
We identified a novel SNP associated with the AAO of PD near the ALCAM gene, distinct from previously reported PD risk loci. These findings need further functional validation; however, they suggest unique genetic pathways influencing the AAO of PD and highlight the need for further research in diverse populations. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Sun Ju Chung (ORCID: https://orcid.org/0000-0003-4118-8233)
- Sang Ryong Jeon (ORCID: https://orcid.org/0000-0002-8340-7978)
- Yun Su Hwang (ORCID: https://orcid.org/0000-0002-8921-0818)
- Kyum‐Yil Kwon (ORCID: https://orcid.org/0000-0001-5443-0952)
- YoonGi Park (ORCID: https://orcid.org/0009-0007-8935-6378)
- Kye Won Park (ORCID: https://orcid.org/0000-0003-2771-249X)
- Yunji Seo (ORCID: https://orcid.org/0000-0003-0314-1805)
- Jae Seung Kim (ORCID: https://orcid.org/0000-0003-1710-1185)
- Eun‐Soon Shin (ORCID: https://orcid.org/0000-0001-8408-2696)
- Sungyang Jo (ORCID: https://orcid.org/0000-0001-5097-2340)
- Seung Hyun Lee (ORCID: https://orcid.org/0000-0001-6710-9383)
- Jae‐Hong Lee (ORCID: https://orcid.org/0000-0001-7368-4560)
Institutions
- Ulsan College (KR)
- Soonchunhyang University Hospital Seoul (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- DNA Link (South Korea) (KR)
- Jeonbuk National University Hospital (KR)
- Gangneung Asan Hospital (KR)
- Jeju National University Hospital (KR)
- Jeonbuk National University (KR)
Publication Details
- Journal
- Movement Disorders
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1002/mds.30047
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Korea Health Industry Development Institute
- Asan Institute for Life Sciences, Asan Medical Center