A multimodal in vitro approach to assess the safety of oral care products using 2D and 3D cellular models
This study highlights the importance of considering exposure time, dosage, and cellular model when assessing the safety of oral care products. While 2D models are useful for preliminary screenings, 3D models provide a more physiologically relevant assessment, emphasizing the need for robust testing protocols to ensure product safety.
Authors
- José Mauro Granjeiro (ORCID: https://orcid.org/0000-0002-8027-8293)
- Rodrigo De Vecchi (ORCID: https://orcid.org/0000-0002-0867-4283)
- Tatiana Miranda Deliberador (ORCID: https://orcid.org/0000-0003-4076-4905)
- Wanderson de Souza (ORCID: https://orcid.org/0000-0002-9632-4928)
- Amanda Lopes
- S. Marceli Leano
Institutions
- Instituto Nacional de Metrologia, Qualidade e Tecnologia (BR)
- Latin American Sepsis Institute (BR)
Publication Details
- Journal
- Frontiers in Toxicology
- Published
- 2024-11-06
- DOI
- https://doi.org/10.3389/ftox.2024.1474583
- Citations
- 6
- Primary Topic
- Dental materials and restorations
- Type
- article
- Field-Weighted Citation Impact
- 2.41
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro