Frequency, Risk Factors and Management of Definite Stent Thrombosis in a Tertiary Care Teaching Hospital in Central India: An Observational Study

Background and objectives: Stent thrombosis is a rare but dreaded complication of coronary intervention. The present study was carried out to investigate the clinical, procedural and lesion factors related to early and late/very late stent thrombosis in patients with stent thrombosis. Methodology: This was a single-centred observational study conducted in central India, among 34 patients with stent thrombosis post percutaneous coronary intervention with drug eluting stent during September 2022 to April 2024. Relevant data were collected through structured questionnaires, hospital records, clinical examination and lab investigations. Frequencies and percentages were calculated. The chi-square test was used to compare the categorical variables and the unpaired t-test for continuous variables, and a p-value of 0.05 was taken as statistically significant. Results: Out of 34 cases, early ST was observed in 20 (58.82%) cases, late in 9 (26.47%) cases, and very late in 5 (14.71%) cases respectively, 21 cases (61.76 %) were male, 28 (82.35 %) were diabetic and 24 (70.58 %) were hypertensive. and 12 (35.29 %) patients reported anti-platelet withdrawal. The mean age of the study participants was 52.4 ?4.2 years. Age of the patients, past history of diabetes mellitus, past history of hypertension, and anti-platelet withdrawal were significantly associated with the timing of ST(p<0.05). Conclusion: The current study concluded that patient age, diabetic status, hypertensive status and antiplatelet withdrawal as factors significantly associated with the timing of stent thrombosis.