Exploring the relationship between polycystic ovarian syndrome, testosterone, and multiple sclerosis in women: A nationwide cohort study and genome-wide cross-trait analysis
We did not find evidence for a causal role of PCOS, as a proxy of elevated testosterone, in reducing the risk of MS in women. The shared genetic loci between testosterone, SHBG, and MS provide biological insights.
Authors
- Qianwen Liu (ORCID: https://orcid.org/0000-0002-1928-4096)
- Tomas Olsson (ORCID: https://orcid.org/0000-0002-2938-1877)
- Pernilla Stridh (ORCID: https://orcid.org/0000-0003-4855-0039)
- Elisabet Stener‐Victorin (ORCID: https://orcid.org/0000-0002-3424-1502)
- Xia Jiang (ORCID: https://orcid.org/0000-0001-5878-8986)
- Elaine Kingwell (ORCID: https://orcid.org/0000-0002-1956-1700)
- Yuan Jiang (ORCID: https://orcid.org/0000-0002-4542-9578)
- Ingrid Skelton Kockum (ORCID: https://orcid.org/0000-0002-0867-4726)
- Klementy Shchetynsky (ORCID: https://orcid.org/0000-0003-4578-5588)
- Carolyn E. Cesta (ORCID: https://orcid.org/0000-0001-5759-9366)
- Ali Manouchehrinia (ORCID: https://orcid.org/0000-0003-4857-5762)
Institutions
- Karolinska Institutet (SE)
- University College London (GB)
Publication Details
- Journal
- Multiple Sclerosis Journal
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1177/13524585241292802
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Karolinska Institutet