Etrinabdione (VCE-004.8), a B55α activator, promotes angiogenesis and arteriogenesis in critical limb ischemia
The findings presented in this study indicate that Etrinabdione holds promise in mitigating endothelial cell damage and senescence, while concurrently fostering arteriogenesis and angiogenesis. These observations position Etrinabdione as a compelling candidate for the treatment of PAD, and potentially other cardiovascular disorders.
Authors
- Isabel Lastres-Cubillo
- Eduardo Muñóz (ORCID: https://orcid.org/0000-0001-8478-5842)
- Carmen Navarrete (ORCID: https://orcid.org/0000-0003-1438-9216)
- Martín Garrido‐Rodríguez (ORCID: https://orcid.org/0000-0003-4125-5643)
- María E. Prados (ORCID: https://orcid.org/0000-0002-2941-4528)
- José Antonio Moreno-Muñoz (ORCID: https://orcid.org/0000-0003-2172-7412)
- Francisco J. Ponce‐Díaz
- Rafael Pineda (ORCID: https://orcid.org/0000-0001-6769-3575)
- Antonio Chacón
- Antonella Medeot
- Laura Cerero
- Adela García‐Martín (ORCID: https://orcid.org/0000-0001-7054-7907)
- Ana Rodríguez
- Javier Moya
- José García-Revillo
- Ígnacio Muñoz (ORCID: https://orcid.org/0000-0002-1157-1891)
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Hospital Universitario Reina Sofía (ES)
- University of Córdoba (ES)
- Cordoba University (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1186/s12967-024-05748-w
- Citations
- 2
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Agencia Estatal de Investigación