The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer
Our data shows that by preventing heparan sulfate breakdown, heparanase inhibitors make TNBC cells more susceptible to chemotherapy by enhancing eATP concentrations.
Authors
- Gina M. Sizemore (ORCID: https://orcid.org/0000-0003-4948-6171)
- Uma Borate (ORCID: https://orcid.org/0000-0002-4958-4962)
- Bhuvaneswari Ramaswamy
- Jasmine M. Manouchehri
- Lynn M. Marcho
- Jharna Datta
- Mark P. Rubinstein (ORCID: https://orcid.org/0000-0003-4748-0286)
- Mathew Cherian (ORCID: https://orcid.org/0000-0002-0380-2012)
- Patrick Schnell (ORCID: https://orcid.org/0000-0002-2343-208X)
- Daniel G. Stover
- Robert Wesolowski
- Ting‐Yuan David Cheng
- Jesse J. Reardon
Institutions
- The Ohio State University (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1186/s13058-024-01906-6
- Citations
- 6
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- Ohio State University