Interactions between sodium hypochlorite, chlorohexidine and citric acid

When sodium hypochlorite (NaOCl) came into contact with chelators, antagonistic interactions included the loss of free accessible chlorine, which decreased the substance's capacity to dissolve tissue and, to a lesser extent, its antibacterial properties. A precipitate that can have negative effects on endodontic therapy, such as discolouration and possible chemical leaching into the periradicular tissues, is created when chlorohexidine (CHX) and NaOCl are combined. Citric acid and NaOCl interactions demineralise the intertubular dentin, which causes the dentinal tubules to open. E. faecalis was eliminated from the main canals of each root by CACHX eighteen hours after irrigation.