Consistency of HFrEF treatment effect in underrepresented groups in randomized clinical trials

Despite the established efficacy of heart failure (HF) guideline-directed medical therapies, implementation varies across demographic groups, including Black, Indigenous, and people of color, older adults, females, and those who are socioeconomically deprived. This review synthesizes the representativeness of trial participants and describes subgroup analyses from pivotal trials in HF with reduced ejection fraction (HFrEF). It reviews the largely consistent treatment effect of medical therapies across the demographic groups represented in trials. It makes arguments for broad implementation of therapies based on these data, while calling for more representative trials to improve research and health equity in HF.

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Publication Details

Journal
npj Cardiovascular Health
Published
2024-11-06
DOI
https://doi.org/10.1038/s44325-024-00028-4
Citations
9
Primary Topic
Heart Failure Treatment and Management
Type
article
Field-Weighted Citation Impact
3.62
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article

Consistency of HFrEF treatment effect in underrepresented groups in randomized clinical trials

Nicolas Girerd, Mark C. Petrie, Javed Butler, Faiez M. Zannad et al.
9 citations
npj Cardiovascular Health
Heart Failure Treatment and Management
3.62
article

Consistency of HFrEF treatment effect in underrepresented groups in randomized clinical trials

Nicolas Girerd, Mark C. Petrie, Javed Butler, Faiez M. Zannad, Ileana L. Piña, Leïla Abid, Harriette G.C. Van Spall, Luca Monzo, Alexandre Mebazaa, Guillaume Baudry
article en
9 citations

Abstract

Despite the established efficacy of heart failure (HF) guideline-directed medical therapies, implementation varies across demographic groups, including Black, Indigenous, and people of color, older adults, females, and those who are socioeconomically deprived. This review synthesizes the representativeness of trial participants and describes subgroup analyses from pivotal trials in HF with reduced ejection fraction (HFrEF). It reviews the largely consistent treatment effect of medical therapies across the demographic groups represented in trials. It makes arguments for broad implementation of therapies based on these data, while calling for more representative trials to improve research and health equity in HF.

npj Cardiovascular HealthVol. 1(1)
University of Sfax (TN), Thomas Jefferson University (US), Inserm (FR), Université Paris Cité (FR), University of Mississippi (US), Sorbonne Paris Cité (FR), Assistance Publique – Hôpitaux de Paris (FR), Hopital Universitaire Hedi Chaker (TN), Baylor Medical Center at Garland (US), Baim Institute for Clinical Research (US), Institut Jean Lamour (FR), French Clinical Research Infrastructure Network (FR), Hamilton Health Sciences (CA), University of Glasgow (GB), École Nationale Supérieure de l'Électronique et de ses Applications (FR), Université de Lorraine (FR), McMaster University (CA)
Openalex Percentile: Top 6%
Heart Failure Treatment and Management
3.62
DOIOpen Access PDFOpenAlex
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