Photoinduced EDA Complex‐Initiated Synthesis of Fluoroalkylated Isoquinolinonediones
A visible-light-induced radical tandem difluoroalkylation/cyclization to construct CF<sub>2</sub>-containing isoquinolinonedione skeletons with methacryloyl benzamides is developed. Broad substrate scopes are compatible with metal-, oxidant- and photocatalyst-free conditions under room temperature in good-to-excellent yields. Mechanistic analysis revealed that the transformation is initiated by photoinduced electron donor-acceptor (EDA) complexes formation.
Authors
- Jiadi Zhou (ORCID: https://orcid.org/0000-0002-3125-2345)
- Lei Huang (ORCID: https://orcid.org/0000-0003-0828-1321)
- Zhi Chen (ORCID: https://orcid.org/0000-0002-2639-1375)
- Chaodong Wang (ORCID: https://orcid.org/0000-0001-8784-1002)
- Shengjie Song
- Jianjun Li (ORCID: https://orcid.org/0000-0002-8490-2639)
- Qianxi Jin
Institutions
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1002/chem.202403286
- Citations
- 9
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.87