Long‐term neuroplasticity in language networks after anterior temporal lobe resection
Neuroplasticity continues for up to ~9 years post-epilepsy surgery in LTLE and RTLE, with effective language recovery linked to bilateral engagement of temporal and extra-temporal regions. This adaptive reorganization is associated with improved cognitive outcomes, challenging the traditional view of localized surgery effects. These findings emphasize the need for early intervention, tailored pre-operative counseling, and the potential for continued cognitive gains with extended post-ATLR rehabilitation.
Authors
- John S. Duncan (ORCID: https://orcid.org/0000-0002-1373-0681)
- David P. Carey (ORCID: https://orcid.org/0000-0001-8860-9731)
- Meneka K. Sidhu (ORCID: https://orcid.org/0000-0003-3267-9348)
- Lawrence P. Binding (ORCID: https://orcid.org/0000-0002-5658-4960)
- Gavin P. Winston (ORCID: https://orcid.org/0000-0001-9395-1478)
- Sallie Baxendale (ORCID: https://orcid.org/0000-0002-9930-6469)
- Maria Sablik (ORCID: https://orcid.org/0000-0001-7113-0660)
- Giovanni d’Avossa (ORCID: https://orcid.org/0000-0002-6298-723X)
- Marine Fleury (ORCID: https://orcid.org/0000-0002-9947-0322)
Institutions
- Bangor University (GB)
- Queen's University (CA)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Epilepsy Society (GB)
Publication Details
- Journal
- Epilepsia
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1111/epi.18147
- Citations
- 5
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- University College London
- University College London Hospitals NHS Foundation Trust
- Epilepsy Society
- Medical Research Council