Evidence-based practices on nanotechnology in wound treatment

Nanotechnology has revolutionized wound treatment by offering innovative solutions that accelerate healing, reduce infections, and promote tissue regeneration. This article reviews evidence-based practices regarding the use of nanotechnology in wound care, with a focus on antimicrobial nanoparticles, smart dressings, and regenerative scaffolds. Studies reviewed between 2010 and 2024 indicate that silver, zinc oxide, and gold nanoparticles are effective in combating antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), thereby preventing infections in chronic and acute wounds. Additionally, smart dressings equipped with embedded sensors have demonstrated the ability to monitor the wound environment, detecting signs of infection or inflammation and delivering drugs in a controlled manner. Another aspect addressed is the use of nanomaterial-based scaffolds, which mimic the extracellular matrix and promote cell proliferation, facilitating tissue regeneration in hard-to-heal wounds, such as diabetic ulcers and severe burns. Although the results are promising, the article highlights the need for more large-scale clinical trials and long-term studies to assess the safety and efficacy of these technologies across diverse populations. Moreover, the high cost of some nanotechnological products remains a challenge for widespread implementation, particularly in resource-limited healthcare systems. The conclusion is that nanotechnology holds great potential to transform wound care, but its broad adoption will depend on further studies, improved accessibility, and greater awareness among healthcare professionals and patients.