Neuroinflammation, Stress-Related Suicidal Ideation, and Negative Mood in Depression
TSPO binding in individuals with depression may be a marker of vulnerability to acute stress-related increases in suicidal ideation and negative affect. Continued study is needed to determine the causal direction of TSPO binding and stress-related suicidal ideation or negative affect and whether targeting neuroinflammation may improve resilience to life stress in patients with depression.
Authors
- J. John Mann
- Elizabeth A. Bartlett (ORCID: https://orcid.org/0000-0002-9174-9951)
- Francesca Zanderigo (ORCID: https://orcid.org/0000-0001-6510-0676)
- Nadine Melhem (ORCID: https://orcid.org/0000-0001-8572-8487)
- E. A. Hauser (ORCID: https://orcid.org/0000-0002-6436-6277)
- Jeffrey Morris Miller (ORCID: https://orcid.org/0000-0002-2206-9311)
- Sarah Herzog (ORCID: https://orcid.org/0000-0001-9161-3061)
- M. Elizabeth Sublette (ORCID: https://orcid.org/0000-0001-7378-4262)
- Akiva Mintz (ORCID: https://orcid.org/0000-0002-9905-3086)
- Mike F. Schmidt (ORCID: https://orcid.org/0000-0003-4721-1457)
- Hanga Galfalvy (ORCID: https://orcid.org/0000-0001-7156-6106)
- Yung‐yu Huang
- Ainsley K. Burke
Institutions
- University of Pittsburgh (US)
- Columbia University Irving Medical Center (US)
- New York State Psychiatric Institute
- Columbia University (US)
Publication Details
- Journal
- JAMA Psychiatry
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1001/jamapsychiatry.2024.3543
- Citations
- 26
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.09