Demonstration of T-Cell Monotypia Using Anti-TCRbeta1/2 (TRBC1/2) Immunostaining as a Rapid and Cost-Effective Alternative to PCR-Based Clonality Studies for the Diagnosis of T-Cell Lymphoma
Analyzing T-cell monotypia immunohistochemically, analogous to B-cell monotypia (kappa: lambda ratio for B-cell and plasma cell neoplasms), could make the diagnosis of T-cell lymphomas cheaper, quicker, and more accurate. Larger studies are needed to validate our antibodies for clinical use.
Authors
- D. Rodgers
- Han-Chieh Yang
- Shelley Evans (ORCID: https://orcid.org/0000-0003-3242-6017)
- Julia Jones (ORCID: https://orcid.org/0000-0001-9819-8091)
- Ivan Smith (ORCID: https://orcid.org/0000-0001-5550-4538)
- Graham S. Ogg (ORCID: https://orcid.org/0000-0002-3097-045X)
- Margaret Ashton‐Key (ORCID: https://orcid.org/0000-0002-7451-363X)
- Elizabeth J. Soilleux (ORCID: https://orcid.org/0000-0002-4032-7249)
- Soo Weei Ng (ORCID: https://orcid.org/0000-0002-9867-6353)
- Venkata N. Konda
- Jodi L. Miller (ORCID: https://orcid.org/0000-0001-6870-204X)
- Rachel Etherington (ORCID: https://orcid.org/0000-0002-4348-4565)
- P Rajesh
- Jie Situ (ORCID: https://orcid.org/0000-0001-7702-0470)
- Maryam Salimi (ORCID: https://orcid.org/0000-0003-3618-6313)
- Jinlong Pang
Institutions
- University of Cambridge (GB)
- Cancer Research UK (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- University of Oxford (GB)
- MRC Weatherall Institute of Molecular Medicine (GB)
Publication Details
- Journal
- Diagnostics
- Published
- 2024-11-06
- DOI
- https://doi.org/10.3390/diagnostics14222479
- Citations
- 6
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.55
Funders
- Pathological Society of Great Britain and Ireland
- University of Cambridge
- Cambridge University Hospitals
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre