Growth Hormone Neuroprotective Effects After an Optic Nerve Crush in the Male Rat
GH has neuroprotective effects in the ONC model in male rats, it promoted RGC survival, gliosis reduction, and axonal transport increase, likely through the regulation of genes involved in neuroprotection, survival, and synaptogenesis. Furthermore, GH prevented functional impairment, indicating its potential as a therapeutic option for retinal neurodegenerative diseases.
Authors
- David Epardo (ORCID: https://orcid.org/0000-0001-5427-8794)
- Carlos G. Martínez-Moreno (ORCID: https://orcid.org/0000-0002-6868-3413)
- Jerusa E. Balderas-Márquez (ORCID: https://orcid.org/0000-0002-8627-0364)
- Martha Carranza (ORCID: https://orcid.org/0000-0001-8894-2067)
- Maricela Luna (ORCID: https://orcid.org/0000-0002-1409-500X)
- J. Luis Quintanar (ORCID: https://orcid.org/0000-0003-1257-7723)
- Stéphanie Thebault (ORCID: https://orcid.org/0000-0003-3233-282X)
- Carlos Arámburo (ORCID: https://orcid.org/0000-0002-6235-8695)
- Cynthia Alejandra Rodríguez-Arzate (ORCID: https://orcid.org/0000-0002-2254-2367)
- José Ávila-Mendoza (ORCID: https://orcid.org/0000-0003-3073-4737)
- Denisse Calderón‐Vallejo (ORCID: https://orcid.org/0000-0003-4509-770X)
Institutions
- Autonomous University of Aguascalientes (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1167/iovs.65.13.17
- Citations
- 3
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- Universidad Nacional Autónoma de México
- Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México